Gladstone Audio News
Gladstone Institutes
Transform your commute or downtime into an opportunity to stay informed with the latest scientific breakthroughs and stories happening at Gladstone Institutes. This isn't your typical podcast—it's your favorite Gladstone articles brought to life through high-quality audio narration, delivered directly to your preferred podcast platform.Each episode features AI-narrated versions of stories from Gladstone's newsroom, allowing you to stay connected to the news that matters most without being tied to a screen. Gladstone Audio News brings you the same compelling storytelling you expect from Gladstone—just in audio form.Subscribe today and never miss a story.New episodes published regu...
Episodes
Novel Biosensor Uses DNA ‘Barcodes’ to Uncover Disease Signals in Cells
Inspired by bacterial biology, the Gladstone-developed “Detectron” opens up new possibilities for disease research and potentially treatments.Read this story on gladstone.orgRead more about the Shipman Lab
How a Single Viral Protein Hijacks Immune Cells to Supercharge COVID-19 Infection
A team of scientists at Gladstone Institutes and UC San Francisco discovered how a SARS-CoV-2 protein reprograms immune cells to accelerate viral spread, pointing to a new strategy for therapeutic intervention.Read this story on our websiteLearn more about the Ott Lab.
Scientists Decode Gene Circuits of Human Immunity, Fueling New Era of Disease Research
An unprecedented map of 22 million immune cells provides the functional rulebook for virtual biology and next-generation immunotherapies.Read this story on gladstone.org.Learn more about the Marson Lab.
New Toolkit Turns Macrophages Into Better Cancer Fighters
A team of scientists from Gladstone and UCSF developed a new method to genetically edit myeloid cells, immune cells that act as the body’s first responders.Read this story on gladstone.org. Learn more about Julia Carnevale's research.
New CRISPR Screening Platform Boosts Power of Immunotherapy Against Solid Tumors
A new screening platform uncovers gene edits that enhance CAR-T cells’ ability to infiltrate and eliminate solid tumors.Read this story on Gladstone.orgRead more about the Marson Lab
Engineered Human Neurons Rebuild Damaged Spinal Cord Circuits
In a new study published in Science Translational Medicine, Gladstone scientists show that stem cell-derived spinal neurons can integrate into damaged neural networks in rats and improve breathing-related motor function after a traumatic spinal cord injury.Read this story on Gladstone.orgLearn more about the Srivastava Lab
Heart Disease Genetic Risk: New Study Reveals Why Populations Differ
For decades, a DNA-based test for cardiovascular disease seemed to work for Europeans and others but not Africans. Gladstone scientists just discovered why, with implications for many other diseases.Read this story on gladstone.orgLearn more about the Tcheandjieu Lab
Misfolded DNA Blueprint: A New Origin for Genetic Disease
By studying a gene linked to congenital heart defects, scientists uncovered a new mechanism for how small drops in protein levels scramble the 3D structure of DNA, resulting in disease.Read this story on gladstone.org.Read the scientific publication.
Controlling Oxygen to Fight Disease
New research shows low oxygen can help alleviate disease caused by defects in a mitochondrial quality control machinery.Read this story on Gladstone.org.Read the scientific publication.
Mapping How the Brain Takes Out Its Trash
Gladstone scientists developed a new tool to trace how the brain clears “waste,” uncovering surprising new biology about how it keeps itself healthy.Read the study, published in Cell.Read this story on gladstone.org.
A Gene That Keeps Stem Cells From Losing Their Way
Thirty years after discovering a gene, Shinya Yamanaka and his team show that it’s essential for keeping intestinal stem cells stable, offering insight into how tissues repair themselves.Read this story on our website.
AI Discovery Reveals DNA Isn’t Locked Away in Cells After All
A new study upends long-held view about how DNA is stored, explaining how subtle shifts in gene activity contribute to cancer, aging, and other complex diseases.Read this story on gladstone.org.
A Universal Toolkit for Editing Bacterial DNA
Scientists at Gladstone expanded their retron-based genome editing technology beyond E. coli, showing it works in 15 diverse bacterial species.Read this article on gladstone.org. Read the scientific publication.
Scientists Map How HIV Hijacks Human Cells—and How Cells Can Fight Back
A team of scientists at Gladstone and UCSF created a new genetic roadmap that reveals hundreds of hidden players in HIV infection, including two proteins that stop HIV in its tracks.Read this story on gladstone.org.Read the scientific publication.
How an Alzheimer’s Risk Gene Disrupts Brain Circuits Long Before Memory Loss
New findings on the APOE4 gene variant point to a potential therapeutic target for Alzheimer’s disease. Read this story on gladstone.org.Read the scientific publication.
New AI Model Predicts How Cells Age
Trained on data spanning the human lifespan, the tool developed at Gladstone can predict genes associated with aging and age-related diseases. Details appear in new study led by Christina Theodoris, MD, PhD, whose team developed the model.Read this story on gladstone.org.Read the preprint.
Why Some People Naturally Control HIV Even After Stopping Therapy—and How We Can Leverage That to Treat Others
A team of Gladstone scientists, led by Nadia Roan, uncovered a new path toward life without daily HIV pills, suggesting that a common diabetes pill could help achieve long-term remission.Read this story on gladstone.org.Read the scientific publication.
New Tool Reveals the Secrets of HIV-Infected Cells
A team of scientists, led by Gladstone Investigator Nadia Roan, developed a novel tool, named HIV-seq, that could uncover new opportunities for treating HIV.Read the scientific publicationRead this story on gladstone.org.
Vitamin B3 Therapy Offers Hope for Fatal Childhood Disease
A new framework that matches vitamins with genetic diseases helped uncover that high-dose vitamin B3 can dramatically extend survival in mice with NAXD deficiency.Read this story on gladstone.orgRead the scientific publication
Red Blood Cells Soak Up Sugar at High Altitude, Protecting Against Diabetes
A team of scientists discovered that red blood cells act as hidden glucose sponges in low-oxygen conditions, explaining why people living at high altitude have lower diabetes rates and pointing toward new treatments.Read this article on gladstone.org.Read the scientific publication.
Disrupted Boundary Between Cell Types Linked to Common Heart Defects
In a new study featured in Nature Cardiovascular Research, Gladstone scientists identified a cellular boundary that guides heart development and revealed how disrupting it can lead to holes in the heart’s wall.Read the scientific publicationRead the article on Gladstone.org
Gene Editing Strategy Could Treat Hundreds of Inherited Diseases More Effectively
A team of scientists at Gladstone developed a new gene editing method and showed that only a few variations of the therapy could treat the majority of patients with Charcot-Marie-Tooth disease.Read this article on gladstone.orgRead the scientific publication.
Genomic Maps Untangle the Complex Roots of Disease
Gladstone Institutes researcher Alex Marson and his collaborators at Stanford University developed a genomic mapping technique that helps close the gap in understanding why certain genetic variants are tied to disease.Read this story on gladstone.org.Read the scientific publication.
The Genome Editing Playbook Is Different in Neurons
A new study by scientists from Gladstone, the Innovative Genomics Institute, and UC Berkeley could influence how gene therapies are designed for many genetic diseases.Read the scientific publicationRead this article on gladstone.org
Evidence Builds for Disrupted Mitochondria as Cause of Parkinson’s
Gladstone Investigator Ken Nakamura led a study that strengthens the links between energy breakdown in cells and the onset of Parkinson’s, potentially illuminating new paths for treatment.Read the scientific publicationRead this article on Gladstone.org
Researchers Reveal Intricate Control System for Key Immune Gene
Scientists at Gladstone Institutes and UC San Francisco learn to fine-tune a gene that is centrally involved in regulating the immune system, offering potential clues for future autoimmunity and cancer treatments.Read the scientific publicationRead the article on Gladstone.org
Rewriting Cellular Instructions to Make Better Tumor-Fighting Immunotherapies
A powerful scientific platform opens new possibilities for treating cancer, autoimmune diseases, and other conditions in which reprogrammed T cells could provide a benefit to patients.Read this article on gladstone.org.Read the scientific publication.
Scientists Pinpoint a Key Gene Behind Heart Defects in Down Syndrome
After decades of mystery, Gladstone researchers identify a gene that can derail heart formation—and show that fixing it prevents the problem in mice.This is an audio version of the article, "Scientists Pinpoint a Key Gene Behind Heart Defects in Down Syndrome," published on Gladstone.org. Read the article on our website.Read the scientific publication.
Overworked Brain Cells May Burn Out in Parkinson’s Disease
A discovery about the consequence of neuron overactivity could lead to new methods of treating or preventing Parkinson’s disease.This is an audio version of the article, "Overworked Brain Cells May Burn Out in Parkinson’s Disease." Read the article on our websiteRead the scientific publication
How Do Vaccines Work?
Listen to this in-depth explainer about different types of vaccines and what happens in the body after vaccination.Read the story on our website.
Blood Vessels and Immune Cells Drive Risk for Alzheimer’s and Stroke
Gladstone scientists, led by Andrew Yang, PhD, show that known genetic risk factors for neurological diseases act in the brain’s blood vessels and immune cells, revealing new targets for therapies.This is an audio version of the article, "Blood Vessels and Immune Cells Drive Risk for Alzheimer’s and Stroke," published on gladstone.org on July 28, 2025. This episode is narrated by an AI-voice. Read this article on our website.Read the scientific publication.
Pregnancy, Lactation Shape Immune Response to COVID-19 Vaccine and Infection
A new study from the Roan lab found strong immune defenses in pregnant and lactating women, with key benefits that could guide future vaccine design.Read more about the study on our website.Read the scientific publication.This is an audio version of the article "Pregnancy, Lactation Shape Immune Response to COVID-19 Vaccine and Infection." This article was read by an AI-voice for accessibility and convenience.
Inside the Brain: Tackling Neurological Disease at Its Roots
From discovering therapies that can repair the brain after stroke to using machine learning to detect early signs of cognitive decline, our researchers are at the forefront of neurological research. In honor of World Brain Day, discover some of Gladstone’s latest breakthroughs.Read this article on our website.Learn more about each of these topics:Stem Cell Therapy Jumpstarts Brain Recovery After Stroke. Read more about this study.Brain Immune Cells Amplify Damage Caused by Alzheimer’s Risk Gene. Read more about this study.Preventing Brain Damage in Preterm Babies. Read more about this study.Machine Learning Reveals Behaviors Linked with Early Alzheimer’s and Points to New Treatments. Read more about this study.Discovery of How Blood Clots Harm Brain and Body in COVID-19 Points to New Therapy. Read more about this study.Powerful New Tool Can Identify Cells Promoting Health or Disease. Read more about this study.A New Therapeutic Target for Traumatic Brain Injury. Read more about this study.Cellular Clean Energy: Can Mitochondria Make More Energy Without Collateral Damage? Read more about this study. Combination of Two Cancer Drugs May Work Against Alzheimer’s. Read more about this study.
Combination of Two Cancer Drugs May Work Against Alzheimer’s
A new study has identified FDA-approved cancer drugs that reverse the gene expression signatures associated with Alzheimer’s.This is an audio version of the article, "Combination of Two Cancer Drugs May Work Against Alzheimer’s," published on gladstone.org on July 21, 2025. This episode is narrated by an AI-voice. MoreRead this article on our website.Read the scientific publication.
From Chaos to Clarity: New Tool Finds Connections in Complex Cell Data
Gladstone scientists, led by Katie Pollard, unveiled a powerful computation tool that integrates different forms of biological data to reveal how cell types are related across tissues, experiments, and species—information that’s crucial for understanding disease.More Read this article on gladstone.org.Read the scientific publication in Cell Genomics.
Bacteria Activate Unusual Defense to Evade Viral Attack
Sukrit Silas and his colleagues discovered that a well-known defense system in some bacteria can kill the cell as a last resort if viruses try to thwart it.Read this article on our website.Read the scientific publication in Molecular Cell.
5 Ways Gladstone Is Harnessing DNA to Overcome Disease
In this audio article, discover how Gladstone scientists are utilizing the power of DNA to deepen our understanding of disease.Read this article on our website. Learn more about each of the topics covered in this episode:Creating a New Guide to Compare DNA Maps Advancing Single-Molecule DNA Sequencing TechnologiesPioneering Gene Editing Techniques with RetronsUsing Next-Gen CRISPR Tool to Create a Map of Immune ResponsesDetermining Genetic Risk in Global Populations
Science Cuts Are a Gamble With Our Health, Our Economy, and Our Future
Gladstone President Deepak Srivastava explains how discoveries from NIH-funded labs spawn innovative new medicines that benefit society and the economy.Read the article on our website.Read more from Srivastava on this topic at the Voice of San Francisco.
Powerful New Tool Can Identify Cells Promoting Health or Disease
Gladstone scientists have developed a computational approach that accurately distinguishes cells of different identities or characteristics in complex biological samples used in diverse areas of biomedical and discovery research.This is an audio version of the article "Powerful New Tool Can Identify Cells Promoting Health or Disease," published on gladstone.org on April 7, 2025. This article is narrated by an AI voice. Read the article on gladstone.org.Read the scientific publication on Nature Genetics.